Symbol
Name
ID

Itk
IL2 inducible T cell kinase
MGI:96621

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgG level

Decreased circulating antibody level

Pancytopenia

Anemia

Autoimmune hemolytic anemia

Decreased proportion of CD4-positive helper T cells

Leukopenia

Hemophagocytosis

Thrombocytopenia

Autoimmune thrombocytopenia

Hodgkin lymphoma

B-cell lymphoma

Lymphoproliferative disorder

Elevated erythrocyte sedimentation rate

Splenomegaly

Disease(s) Associated with ITK

lymphoproliferative syndrome 1

Mouse Phenotypes

increased CD8-positive, alpha-beta memory T cell proliferation

decreased T cell proliferation

abnormal thymus cell ratio

enlarged spleen

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal positive T cell selection

increased double-negative T cell number

increased germinal center B cell number

decreased B cell number

increased B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

increased mature gamma-delta T cell number

increased memory T cell number

decreased T cell number

abnormal T cell morphology

abnormal NK T cell morphology

abnormal gamma-delta T cell morphology

abnormal spleen morphology

increased IgE level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Itk^em1(IMPC)Mbp/Itk^em1(IMPC)Mbp

Itk^m1Btlr/Itk^m1Btlr

Itk^m2Btlr/Itk^m2Btlr

Itk^tm1Lex/Itk^tm1Lex

Itk^tm1Litt/Itk^tm1Litt

Itk^tm1Ljb/Itk^tm1Ljb

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23